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So, we recommend using SL vitamin B12 rather than oral and IM, especially in patients who do not tolerate IM injection and patients who need prolonged vitamin B12 supplementation, such as patients with long-term metformin use and patients with pernicious anemia or with gastro-duodenal resection [51,52,53,54]

At the same time, the equity questions are just as important as the efficacy curves: Who will actually have access to orforglipron once it is approved

This dual mechanism gives tirzepatide a unique advantage over GLP-1-only medications like Wegovy

Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M (2019) Cellular Senescence: Defining a Path Forward

J Mol Med

-Inositol Converts food into energy